We previously demonstrated that preincubation with docosahexaenoic acid (DHA) reduces prostaglandin (PG) E-2 production stimulated by IL-1. OBJECTIVE: Omega-3 fatty acid (n-3 FA) supplementation during pregnancy hasīeen shown to decrease the incidence of SPTB. York, 2University of Texas Health Science Center at San Antonio, Obstetrics and NATHANIELSZ2, 1New York University, Obstetrics and Gynecology, New York, New TRAFFICKING OF PROSTANOID ENZYMES IN CULTURED HUMAN DECIDUAL CELLS:Ī POTENTIAL MECHANISM BY WHICH N-3 FA INHIBIT SPONTANEOUS PRETERMīIRTH (SPTB) ASHLEY ROMAN1, GREG DORSAINVILLE1, SEAN KEELER1, PETER OMEGA-3 FATTY ACIDS (N-3 FA) INHIBIT IL-1-INDUCED SYNTHESIS AND Spontaneous PTB rates according to cerclage height.ĬONCLUSION: Cerclage height of ⱖ 20 mm is associated with a reduction in To age, race, history of PTB, gestational age and CL time of cerclage. The baseline characteristics were similar between cerclage height groups according RESULTS: After exclusions a total of 70 women were included in the analysis. Was performed using SPSS version 13, Chicago Il. ANOVA was performed forĬontinuous variables. Chisquare analysis was performed for categorical variables. Our primary outcome was spontaneous PTB ⬍35 weeks. Patients were categorized by cerclage height: ⬍ 10 mm, 10-19 The following measurements were obtained: functional CL (closed portion of theĮndocervical canal), and the cerclage height (the distance from cerclage to theĮxternal cervical os). Ultrasound measurements obtained prior to cerclage placement and theįirst ultrasound after cerclage placement, (⬍ 24 week) were used for data analysis. Patients with multiple gestations, indicated PTB, history indicated cerclage, manualĮxam indicated cerclage, transabdominal cerclage and major fetal anomalies wereĮxcluded. Our data source was the Thomas Jefferson University Prematurity Database, and the Main Line Hospitals= cerclage database. We defined UC as a cerclage placedįor a short CL (⬍25mm), detected by transvaginal ultrasound between 14-23 6/7 Received an ultrasound indicated cerclage (UC). STUDY DESIGN: We performed a retrospective cohort study of women who OBJECTIVE: This study is intended to determine if the cerclage height is associated with spontaneous preterm birth (PTB) in patients with an ultrasound indicated cerclage. The Lankenau Hospital, Obstetric and Gynecology, Wynnewood, Pennsylvania VINCENZO BERGHELLA1, 1Thomas Jefferson University, Philadelphia, Pennsylvania,
SCHEIB1, GENNADY MIROSHNICHENKO2, CHRISTOPHER HARVEY1, KEITH RYCHLAK1, WOMEN WITH AN ULTRASOUND INDICATED CERCLAGE? JOHN VISINTINE1, STACEY
IS CERCLAGE HEIGHT ASSOCIATED WITH PREVENTION OF PRETERM BIRTH FOR